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Molecular Profile ALK amp TP53 wild-type
Therapy Crizotinib + Cyclophosphamide + Topotecan
Indication/Tumor Type neuroblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK amp TP53 wild-type neuroblastoma sensitive Crizotinib + Cyclophosphamide + Topotecan Preclinical - Cell culture Actionable In a preclinical study, Xalkori (crizotinib) demonstrated synergy with the combination of Topotecan and Cytoxan (cyclophosphamide) in neuroblastoma cell lines harboring Alk amplification and functional TP53, resulting in growth inhibition in culture (PMID: 26438783). 26438783
PubMed Id Reference Title Details
(26438783) Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma. Full reference...