Profile Response Detail

Molecular Profile PTEN loss
Therapy AT13148
Indication/Tumor Type uterine corpus sarcoma
Response Type sensitive
Create By c-seddy
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss uterine corpus sarcoma sensitive AT13148 Preclinical - Cell line xenograft Actionable In a preclinical study, AT13148 inhibited tumor growth in a PTEN-deficient human uterine sarcoma cell line xenograft model (PMID: 22781553). 22781553
PubMed Id Reference Title Details
(22781553) AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Full reference...