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Molecular Profile DDR2 L63V
Therapy Nilotinib + Saracatinib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 L63V Advanced Solid Tumor sensitive Nilotinib + Saracatinib Preclinical Actionable In a preclinical study, the combination of Saracatinib (AZD0530) with Tasigna (nilotinib) reduced Src and Stat5 activation and inhibited proliferation of transformed cells expressing DDR2 L63V in culture, with increased potency over either agent alone (PMID: 22328973). 22328973
PubMed Id Reference Title Details
(22328973) Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Full reference...