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Molecular Profile RET C634W
Therapy XMD15-44
Indication/Tumor Type thyroid gland medullary carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W thyroid gland medullary carcinoma sensitive XMD15-44 Preclinical Actionable In a preclinical study, XMD15-44 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET C634W in culture (PMID: 26046350). 26046350
PubMed Id Reference Title Details
(26046350) Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. Full reference...