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Molecular Profile Unknown unknown
Therapy PI-3065
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown pancreatic ductal adenocarcinoma not applicable PI-3065 Preclinical Actionable In a preclinical study, treatment with the PIK3-delta inhibitor PI-3065 resulted in increased host anti-tumor immune response and led to prolonged survival and decreased metastasis in an mouse model of KRAS G12D and TP53 R175H-expressing pancreatic ductal adenocarcinoma (PMID: 24919154). 24919154
PubMed Id Reference Title Details
(24919154) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Full reference...