Profile Response Detail

Molecular Profile EML4-ALK ALK G1269A
Therapy Ceritinib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By c-seddy
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4-ALK ALK G1269A Advanced Solid Tumor sensitive Ceritinib Preclinical - Cell culture Actionable In a preclinical study, Zykadia (ceritinib) inhibited growth of transformed cells expressing EML4-ALK with ALK G1269A in culture (PMID: 27009859). 27009859
PubMed Id Reference Title Details
(27009859) TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors. Full reference...