Profile Response Detail

Molecular Profile NPM1-ALK ALK I1171T
Therapy ASP3026
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant
Create By c-seddy
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1-ALK ALK I1171T Advanced Solid Tumor resistant ASP3026 Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing NPM1-ALK with ALK I1171T were resistant to ASP3026 in culture (PMID: 25749034). 25749034
PubMed Id Reference Title Details
(25749034) NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922. Full reference...