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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NPM1 - ALK ALK I1171T||Advanced Solid Tumor||resistant||Brigatinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells expressing NPM1-ALK with ALK I1171T were resistant to Alunbrig (brigatinib) in culture (PMID: 25749034).||25749034|