Profile Response Detail

Molecular Profile NPM1-ALK ALK F1174I
Therapy Alectinib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By c-seddy
Update By tyin

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1-ALK ALK F1174I Advanced Solid Tumor sensitive Alectinib Preclinical - Cell culture Actionable In a preclinical study, Alecensa (alectinib) inhibited growth of transformed cells expressing NPM1-ALK with ALK F1174I in culture (PMID: 25749034). 25749034
PubMed Id Reference Title Details
(25749034) NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922. Full reference...