Profile Response Detail

Molecular Profile IDH1 R132H
Therapy AGI-5198 + Radiotherapy
Indication/Tumor Type colorectal cancer
Response Type resistant
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H colorectal cancer resistant AGI-5198 + Radiotherapy Preclinical Actionable In a preclinical study, colorectal cancer cells expressing IDH1 R132H were resistant to radiotherapy when treated with AGI-5198 (PMID: 26363012). 26363012
PubMed Id Reference Title Details
(26363012) Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Full reference...