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Molecular Profile | Unknown unknown |
Therapy | Metformin + Temsirolimus |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | Advanced Solid Tumor | not applicable | Metformin + Temsirolimus | Phase I | Actionable | In a Phase I clinical trial, the combination of Torisel (temsirolimus) and Glucophage (metformin) demonstrated safety and resulted in a clinical benefit rate of 22% in patients with advanced or refractory tumors, with 4/18 patients achieving stable disease for greater than 6 cycles (PMID: 27014780). | 27014780 |
PubMed Id | Reference Title | Details |
---|---|---|
(27014780) | Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers. | Full reference... |