Profile Response Detail

Molecular Profile KRAS G13D
Therapy Palbociclib + Trametinib
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By tyin
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G13D colorectal cancer sensitive Palbociclib + Trametinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Mekinist (trametinib) and Ibrance (palbociclib) synergistically inhibited growth of colorectal cancer cells harboring KRAS G13D in culture and resulted in partial tumor regression in patient-derived xenograft models (PMID: 26369631). 26369631
PubMed Id Reference Title Details
(26369631) Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. Full reference...