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Molecular Profile | ETV6 - ROS1 |
Therapy | Entrectinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ETV6 - ROS1 | Advanced Solid Tumor | sensitive | Entrectinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, transformed cells expressing ETV6-ROS1 were sensitive to Rozlytrek (entrectinib), resulting in inhibition of cell proliferation in culture and decreased tumor growth in xenograft models (PMID: 26939704). | 26939704 |
PubMed Id | Reference Title | Details |
---|---|---|
(26939704) | Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. | Full reference... |