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Molecular Profile | SRC positive |
Therapy | KX2-391 |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SRC positive | triple-receptor negative breast cancer | sensitive | KX2-391 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, KX2-392 inhibited Src signaling and proliferation in triple-receptor negative breast cancer cell lines in culture, and suppressed tumor growth in xenograft models (PMID: 22784709). | 22784709 |
PubMed Id | Reference Title | Details |
---|---|---|
(22784709) | Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. | Full reference... |