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Molecular Profile SRC positive
Therapy KX2-391 + Paclitaxel
Indication/Tumor Type triple-receptor negative breast cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SRC positive triple-receptor negative breast cancer sensitive KX2-391 + Paclitaxel Preclinical - Cell line xenograft Actionable In a preclinical study, KX2-392 and Taxol (paclitaxel) worked synergistically to inhibit Src signaling and proliferation of triple-receptor negative breast cancer cell lines in culture, and induced tumor regression and suppressed metastasis in xenograft models (PMID: 22784709). 22784709
PubMed Id Reference Title Details
(22784709) Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Full reference...