Molecular Profile | ERBB2 exon 20 ins |
Therapy | AP32788 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Create By | tyin |
Update By | smockus |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | ERBB2 exon 20 ins | Advanced Solid Tumor | sensitive | AP32788 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, AP32788 inhibited growth of transformed cell lines over expressing ERBB2 (HER2) exon 20 insertions in culture, and induced tumor regression in PDX models (AACR, Cancer Res: April 2016; Volume 57, Abstract #2644). | detail... |
---|
PubMed Id | Reference Title | Details |
---|---|---|
AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models | Full reference... |