Profile Response Detail

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Molecular Profile VHL over exp
Therapy Cediranib + Saracatinib
Indication/Tumor Type clear cell renal cell carcinoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
VHL over exp clear cell renal cell carcinoma no benefit Cediranib + Saracatinib Phase II Actionable In a Phase II clinical study, baseline expression of VHL was not predictive for response to Saracatinib (AZD0530) and Recentin (cediranib) relative to Recentin (cediranib) in patients with metastatic clear-cell renal cell carcinoma (PMID: 26802156). 26802156
PubMed Id Reference Title Details
(26802156) A randomized, double-blind phase II study evaluating cediranib versus cediranib and saracatinib in patients with relapsed metastatic clear-cell renal cancer (COSAK). Full reference...