Profile Response Detail

Molecular Profile MSH6 mutant
Therapy N/A
Indication/Tumor Type colorectal cancer
Response Type not applicable
Create By spatt
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MSH6 mutant colorectal cancer not applicable N/A Clinical Study Diagnostic Germline mutations in MSH6 are associated with microsatellite instability in colorectal cancer (CRC), and are diagnostic for Lynch syndrome (hereditary nonpolyposis colorectal cancer) in colorectal cancer patients (PMID: 26582061; PMID: 19125127). 26582061 19125127
PubMed Id Reference Title Details
(26582061) Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer. Full reference...
(19125127) EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. Full reference...