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Molecular Profile KDR amp
Therapy Vandetanib
Indication/Tumor Type lung non-small cell carcinoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KDR amp lung non-small cell carcinoma no benefit Vandetanib Phase III Actionable In a retrospective analysis of a Phase III trial, treatment with Caprelsa (vandetanib) did not correlate with an improved PFS, OS, or objective response rate in non-small cell lung carcinoma patients harboring a KDR amplification nor did it inhibit cell proliferation of the KDR amplified archived tumor cells in culture (PMID: 26578684). 26578684
PubMed Id Reference Title Details
(26578684) KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib. Full reference...