Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RUNX1 - RUNX1T1||acute myeloid leukemia||not applicable||N/A||Guideline||Prognostic||RUNX1-RUNX1T1 fusions (t(8;21)(q22;q22.1)) are associated with a favorable prognosis in patients with non-APL acute myeloid leukemia (NCCN.org).||detail...|
|RUNX1 - RUNX1T1||acute myeloid leukemia||not applicable||N/A||Clinical Study||Prognostic||In clinical analyses, the t(8;21) cytogenetic abnormality, which leads to the RUNX1-RUNX1T1 fusion, is associated with core-binding factor acute myeloid leukemia and favorable prognosis (PMID: 22180162, PMID: 9746770, PMID: 25111512).||9746770 25111512 22180162|
|PubMed Id||Reference Title||Details|
|(22180162)||Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management.||Full reference...|
|(9746770)||The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.||Full reference...|
|(25111512)||Identification of molecular and cytogenetic risk factors for unfavorable core-binding factor-positive adult AML with post-remission treatment outcome analysis including transplantation.||Full reference...|