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Molecular Profile CEBPA mutant
Therapy N/A
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CEBPA mutant acute myeloid leukemia not applicable N/A Guideline Prognostic CEBPA biallelic mutations are associated with a favorable prognosis in patients with non-APL acute myeloid leukemia ( detail...
CEBPA mutant acute myeloid leukemia not applicable N/A Clinical Study Prognostic In clinical analyses, biallelic CEBPA mutations were associated with favorable clinical outcome in patients with cytogenetically normal acute myeloid leukemia (PMID: 26601784, PMID: 19171880, PMID: 20038735, PMID: 22915647). 22915647 26601784 19171880 20038735
PubMed Id Reference Title Details
(26601784) The multifaceted functions of C/EBPα in normal and malignant haematopoiesis. Full reference...
(19171880) Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Full reference...
(20038735) Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. Full reference...
(22915647) A novel hierarchical prognostic model of AML solely based on molecular mutations. Full reference... Full reference...