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Molecular Profile ASXL1 wild-type TET2 mut
Therapy Decitabine
Indication/Tumor Type myelodysplastic/myeloproliferative neoplasm
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ASXL1 wild-type TET2 mut myelodysplastic/myeloproliferative neoplasm sensitive Decitabine Clinical Study - Cohort Actionable In a clinical study, myelodysplastic syndrome patients carrying TET2 mutations and wild-type ASXL1 demonstrated an increased response to treatment with the DNA hypomethylating agents Dacogen (decitabine) or Vidaza (azacitidine) compared to patients with other mutational profiles (65% vs. 44%; OR 2.37, P=0.49) (PMID: 25224413). 25224413
PubMed Id Reference Title Details
(25224413) TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Full reference...