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Molecular Profile | Unknown unknown |
Therapy | Zebularine |
Indication/Tumor Type | cholangiocarcinoma |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | cholangiocarcinoma | not applicable | Zebularine | Preclinical - Cell culture | Actionable | In a preclinical study, Zebularine treatment decreased DNMT1 expression,and induced apoptosis in cholangiocarcinoma cell lines in culture (PMID: 25799509). | 25799509 |
PubMed Id | Reference Title | Details |
---|---|---|
(25799509) | DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status. | Full reference... |