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Molecular Profile | ATRX loss |
Therapy | Doxorubicin |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATRX loss | glioblastoma | sensitive | Doxorubicin | Preclinical | Actionable | In a preclinical study, loss of ATRX sensitized glioblastoma cell lines to double-stranded DNA-damaging agents, including Adriamycin (doxorubicin), Topotecan, and Camptosar (irinotecan) in culture (PMID: 26936505). | 26936505 |
PubMed Id | Reference Title | Details |
---|---|---|
(26936505) | ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. | Full reference... |