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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|GATA2 mutant||acute myeloid leukemia||not applicable||N/A||Clinical Study||Prognostic||In multiple clinical studies, GATA2 germline mutations were shown to be a risk factor for the development of acute myeloid leukemia following myelodysplastic syndrome (PMID: 21892162, PMID: 22271902, PMID: 22147895, PMID: 22533337).||22533337 22271902 22147895 21892162|
|PubMed Id||Reference Title||Details|
|(21892162)||Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.||Full reference...|
|(22271902)||Germ-line GATA2 p.THR354MET mutation in familial myelodysplastic syndrome with acquired monosomy 7 and ASXL1 mutation demonstrating rapid onset and poor survival.||Full reference...|
|(22147895)||Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.||Full reference...|
|(22533337)||Marked genetic heterogeneity in familial myelodysplasia/acute myeloid leukaemia.||Full reference...|