Profile Response Detail

Molecular Profile SMO W281C
Therapy Sonidegib
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO W281C Advanced Solid Tumor decreased response Sonidegib Preclinical Actionable In a preclinical study, primary cerebellar granule neuron precursor cells over expressing SMO W281C on the background of PTCH1 and TP53 deletion demonstrated reduced response to Odomzo (sonidegib) induced growth inhibition in cell culture (PMID: 25759019). 25759019
PubMed Id Reference Title Details
(25759019) Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Full reference...