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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|CSF3R mutant||bone marrow cancer||not applicable||N/A||Clinical Study||Emerging||In clinical studies, high frequency of CSF3R mutations was identified in patients with chronic neutrophilic leukemia (PMID: 23656643, PMID: 24081659), suggesting that this may serve as a future diagnostic biomarker (PMID: 24441292).||24081659 23656643 24441292|
|PubMed Id||Reference Title||Details|
|(23656643)||Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.||Full reference...|
|(24081659)||The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition.||Full reference...|
|(24441292)||An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms.||Full reference...|