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Molecular Profile FGFR3 - TACC3
Therapy Alpelisib + Infigratinib
Indication/Tumor Type transitional cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - TACC3 transitional cell carcinoma predicted - sensitive Alpelisib + Infigratinib Phase I Actionable In a Phase Ib trial, Infigratinib (BGJ398) and Alpelisib (BYL719) combination treatment resulted in partial response and a complete shrinkage of target lesions lasting 4 months in one urothelial carcinoma patient harboring a FGFR3-TACC3 fusion (J Clin Oncol 34, 2016 (suppl; abstr 2500)). detail...
PubMed Id Reference Title Details
Phase Ib study of BGJ398 in combination with BYL719 in patients (pts) with select advanced solid tumors. Full reference...