Profile Response Detail

Molecular Profile BRAF mutant
Therapy Trametinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By c-seddy
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF mutant lung adenocarcinoma sensitive Trametinib Preclinical Actionable In a preclinical study, Mekinist (trametinib) inhibited growth of lung adenocarcinoma cells harboring mutant BRAF in culture (PMID: 26343583). 26343583
PubMed Id Reference Title Details
(26343583) Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Full reference...