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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK fusion||lung non-small cell carcinoma||sensitive||Lorlatinib||FDA approved||Actionable||In a Phase II trial that supported FDA approval, Lorbrena (lorlatinib) treatment resulted in an objective response (OR) rate of 47% (93/198; 4 CR, 89 PR) and a median time to overall first tumor response of 1.4 months, and an objective intracranial response rate of 63% (51/81) and median time to first intracranial response of 1.4 months in ALK-positive (rearrangement or fusion) non-small cell lung cancer patients who had received at least one prior ALK inhibitor therapy (PMID: 30413378; NCT01970865).||detail... 30413378|
|ALK fusion||lung non-small cell carcinoma||sensitive||Lorlatinib||Phase I||Actionable||In a Phase I trial, Lorlatinib (PF-06463922) demonstrated safety and resulted in a 50% (26/52) overall response rate in patients with ALK-positive or ROS1-positive non-small cell lung cancer, including intracranial responses in patients with CNS metastasis (J Clin Oncol 34, 2016 (suppl; abstr 9009)).||detail...|
|PubMed Id||Reference Title||Details|
|Safety and efficacy of lorlatinib (PF-06463922) from the dose-escalation component of a study in patients with advanced ALK+ or ROS1+ non-small cell lung cancer (NSCLC).||Full reference...|
|(30413378)||Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study.||Full reference...|
|Lorbrena (lorlatinib) FDA Drug Label||Full reference...|