Profile Response Detail

Molecular Profile BRAF V600E BRAF T529M
Therapy SB590885
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - resistant
Create By c-seddy
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E BRAF T529M Advanced Solid Tumor predicted - resistant SB590885 Preclinical Actionable In a preclinical study, transformed cells expressing BRAF V600E and the gatepkeeper mutation BRAF T529M were insensitive to SB590885-mediated inhibition of ERK signaling in culture (PMID: 20538618). 20538618
PubMed Id Reference Title Details
(20538618) Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Full reference...