Profile Response Detail

Molecular Profile Unknown unknown
Therapy LY3039478
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable
Create By cstatz
Update By tyin

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable LY3039478 Phase I Actionable In a Phase I trial, treatment with LY3039478 was well-tolerated and demonstrated some preliminary efficacy in patients with advanced solid tumors (J Clin Oncol 33, 2015 (suppl; abstr 2533)). detail...
Unknown unknown Advanced Solid Tumor not applicable LY3039478 Phase I Actionable In a Phase I trial, LY3039478 treatment resulted in 80% inhibition of plasma A-beta and more than 50% inhibition of Notch1-regulated genes in patients with advanced solid tumor, leading to partial response in 0.9% (1/110) and stable disease in 32.7% (36/110) of the patients (PMID: 30060061; NCT01695005). 30060061 detail...
PubMed Id Reference Title Details
First-in-human study of LY3039478, a Notch signaling inhibitor in advanced or metastatic cancer Full reference...
First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer Full reference...
(30060061) First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer. Full reference...