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Molecular Profile | SRC positive |
Therapy | UM-164 |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SRC positive | triple-receptor negative breast cancer | predicted - sensitive | UM-164 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, UM-164 inhibited proliferation and induced apoptosis in human triple-receptor negative breast cancer cell lines with elevated Src activity in culture, and inhibited tumor growth in cell line xenograft models (PMID: 27154914). | 27154914 |
PubMed Id | Reference Title | Details |
---|---|---|
(27154914) | UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer. | Full reference... |