Profile Response Detail


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Molecular Profile ERBB2 V777L
Therapy Neratinib + Trastuzumab
Indication/Tumor Type colorectal cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 V777L colorectal cancer sensitive Neratinib + Trastuzumab Preclinical - Cell line xenograft Actionable In a preclinical study, Herceptin (trastuzumab) and Nerlynx (neratinib) combination treatment inhibited growth of colorectal cancer cells over expressing ERBB2 (HER2) V777L in culture and suppressed tumor growth in cell line xenograft models (PMID: 26243863). 26243863
PubMed Id Reference Title Details
(26243863) HER2 activating mutations are targets for colorectal cancer treatment. Full reference...