Profile Response Detail

Molecular Profile ERBB2 amp ERBB2 L866M
Therapy Neratinib + Trastuzumab
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By tyin
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 amp ERBB2 L866M colorectal cancer sensitive Neratinib + Trastuzumab Preclinical Actionable In a preclinical study, Herceptin (trastuzumab) and Nerlynx (neratinib) combination treatment resulted in sustained tumor regression in xenograft models of patient derived colorectal cancer cells harboring ERBB2 (HER2) L866M and ERBB2 (HER2) amplification (PMID: 26243863). 26243863
PubMed Id Reference Title Details
(26243863) HER2 activating mutations are targets for colorectal cancer treatment. Full reference...