Molecular Profile | PDGFRA V658A |
Therapy | Imatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Create By | tyin |
Update By | tyin |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | PDGFRA V658A | Advanced Solid Tumor | sensitive | Imatinib | Preclinical | Actionable | In a preclinical study, crenolanib inhibited Pdgfra phosphorylation and decreased proliferation in transformed human cells expressing PDGFRA V658A in culture (PMID: 24132921). | 24132921 |
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PubMed Id | Reference Title | Details |
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(24132921) | Large-scale analysis of PDGFRA mutations in melanomas and evaluation of their sensitivity to tyrosine kinase inhibitors imatinib and crenolanib. | Full reference... |