Profile Response Detail


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Molecular Profile ERBB4 E317K
Therapy Lapatinib
Indication/Tumor Type melanoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB4 E317K melanoma sensitive Lapatinib Preclinical - Cell culture Actionable In a preclinical study, Tykerb (lapatinib) inhibited growth and induced apoptosis in melanoma cells harboring ERBB4 E317K in culture (PMID: 19718025). 19718025
PubMed Id Reference Title Details
(19718025) Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Full reference...