Profile Response Detail

Molecular Profile APC mutant
Therapy K-756
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By spatt
Update By djd


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC mutant colorectal cancer predicted - sensitive K-756 Preclinical Actionable In a preclinical study, K-756 inhibited Wnt signaling and reduced growth of 2/3 tested APC-mutant colorectal cancer cell lines in culture (PMID: 27196752). 27196752
PubMed Id Reference Title Details
(27196752) The Discovery and Characterization of K-756, a Novel Wnt/β-Catenin Pathway Inhibitor Targeting Tankyrase. Full reference...