Profile Response Detail

Molecular Profile ABL1 G321L
Therapy Dasatinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By spatt
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ABL1 G321L lung adenocarcinoma sensitive Dasatinib Preclinical Actionable In a preclinical study, treatment with Sprycel (dasatinib) in decreased CRKL phosphorylation and reduced viability of lung adenocarcinoma cells harboring ABL1 G321L (also reported as G340L) in culture (PMID: 26758680). 26758680
PubMed Id Reference Title Details
(26758680) Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. Full reference...