Profile Response Detail

Molecular Profile KRAS mutant
Therapy Ponatinib + Trametinib
Indication/Tumor Type colon cancer
Response Type decreased response
Create By tyin
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant colon cancer decreased response Ponatinib + Trametinib Preclinical Actionable In a preclinical study, Mekinist (trametinib) and Iclusig (ponatinib) combination treatment was less efficient at inhibiting proliferation of KRAS mutant colon cancer cells in culture (PMID: 27338794). 27338794
PubMed Id Reference Title Details
(27338794) A combinatorial strategy for treating KRAS-mutant lung cancer. Full reference...