Profile Response Detail

Molecular Profile ERBB2 exon 20 ins
Therapy Afatinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive
Create By spatt
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 exon 20 ins lung adenocarcinoma predicted - sensitive Afatinib Case Reports/Case Series Actionable In a clinical study, treatment with pulse Gilotrif (afatinib) resulted in an objective response rate of 33.3% (1/3) in lung adenocarcinoma patients with ERBB2 (HER2) exon 20 insertion mutations (PMID: 26964772). 26964772
PubMed Id Reference Title Details
(26964772) Pulse Afatinib for ERBB2 Exon 20 Insertion-Mutated Lung Adenocarcinomas. Full reference...