Profile Response Detail

Molecular Profile ERBB2 Y772_A775dup
Therapy Afatinib
Indication/Tumor Type lung adenocarcinoma
Response Type conflicting
Create By spatt
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 Y772_A775dup lung adenocarcinoma conflicting Afatinib Case Reports/Case Series Actionable In a clinical study, a lung adenocarcinoma patient harboring ERBB2 Y772_A775dup (also referred to as A775_G776insYVMA and E740_A741insAYVM) achieved a partial response for 5 months following treatment with pulse Gilotrif (afatinib), however, a second patient harboring ERBB2 Y772_A775dup treated with pulse Gilotrif (afatinib) demonstrated progressive disease (PMID: 26964772). 26964772
PubMed Id Reference Title Details
(26964772) Pulse Afatinib for ERBB2 Exon 20 Insertion-Mutated Lung Adenocarcinomas. Full reference...