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Molecular Profile | FGFR3 K650E |
Therapy | AZD4547 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 K650E | Advanced Solid Tumor | decreased response | AZD4547 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells over expressing FGFR3 K650E demonstrated reduced sensitivity to growth inhibition by AZD4547 in culture (PMID: 26992226). | 26992226 |
PubMed Id | Reference Title | Details |
---|---|---|
(26992226) | Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. | Full reference... |