Profile Response Detail

Molecular Profile KRAS G13D
Therapy APS-2-79 + Trametinib
Indication/Tumor Type colon cancer
Response Type sensitive
Create By spatt
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G13D colon cancer sensitive APS-2-79 + Trametinib Preclinical - Cell culture Actionable In a preclinical study, the combination of APS-2-49 and Mekinist (trametinib) worked synergistically to decrease viability of a colon cancer cell line harboring KRAS G13D in culture (PMID: 27556948). 27556948
PubMed Id Reference Title Details
(27556948) Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Full reference...