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Molecular Profile Unknown unknown
Therapy Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone
Indication/Tumor Type acute myeloid leukemia
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone Phase I Actionable In a Phase I trial, Rydapt (midostaurin), in combination with Velcade (bortezomib) and mitoxantrone, Vepesid (etoposide), and Cytosar-U (cytarabine) (MEC), resulted in an overall response rate of 82.5% (19/23) in patients with relapsed or refractory acute myeloid leukemia receiving dose level 3 and above, with complete responses in 56.5% (13/23) of patients (PMID: 26784138). 26784138
PubMed Id Reference Title Details
(26784138) Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia. Full reference...