Profile Response Detail

Molecular Profile MAP2K1 K57N
Therapy Selumetinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By stafford
Update By c-spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57N lung adenocarcinoma sensitive Selumetinib Preclinical Actionable In a preclinical study, selumetinib (AZD6244) inhibited phosphorylation of ERK in cells expressing MAP2K1 K57N and inhibited MAP2K1 K57N-dependent growth in cell culture (PMID: 18632602). 18632602
PubMed Id Reference Title Details
(18632602) Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Full reference...