Molecular Profile | Unknown unknown |
Therapy | OMP-305B83 |
Indication/Tumor Type | colon cancer |
Response Type | not applicable |
Create By | spatt |
Update By | spatt |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | Unknown unknown | colon cancer | not applicable | OMP-305B83 | Preclinical | Actionable | In a preclinical study, OMP-305B83 inhibited proliferation of endothelial cells in culture and demonstrated antitumor activity in vivo in multiple solid tumor types, including colon tumors (Mol Cancer Ther December 2015 14; C164). | detail... |
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PubMed Id | Reference Title | Details |
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Abstract C164: Dual targeting of the DLL4 and VEGF pathways with a bispecific monoclonal antibody inhibits tumor growth and reduces cancer stem cell frequency | Full reference... |