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Molecular Profile RSPO3 fusion
Therapy GSK3178022
Indication/Tumor Type colorectal cancer
Response Type conflicting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RSPO3 fusion colorectal cancer conflicting GSK3178022 Preclinical - Pdx Actionable In a preclinical study, GSK3178022 inhibited Wnt signaling and delayed tumor growth in a patient-derived xenograft (PDX) model of colorectal cancer harboring an RSPO3 translocation, however, failed to inhibit Wnt signaling or tumor growth in a second RSPO3 translocation-positive colorectal cancer PDX model (PMID: 27401612). 27401612
PubMed Id Reference Title Details
(27401612) Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth. Full reference...