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Molecular Profile TP53 wild-type
Therapy PD-0325901 + Sapanisertib
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type colorectal cancer predicted - sensitive PD-0325901 + Sapanisertib Preclinical - Pdx & cell culture Actionable In a preclinical study, Sapanisertib (MLN0128) and PD-0325901 synergistically induced apoptosis in TP53 wild-type but not TP53 mutated colorectal cancer cell lines in culture, and demonstrated anti-tumor activity in TP53 wild-type but not TP53 mutated patient-derived xenograft models (PMID: 26272063). 26272063
PubMed Id Reference Title Details
(26272063) MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer. Full reference...