Profile Response Detail

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Molecular Profile KIT D820Y
Therapy Sorafenib
Indication/Tumor Type melanoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT D820Y melanoma predicted - sensitive Sorafenib Case Reports/Case Series Actionable In a clinical case study, Nexavar (sorafenib) treatment resulted in stable disease with 27% reduction in target lesions at 4 weeks in a patient with anal melanoma and pulmonary metastases harboring KIT D820Y (PMID: 20372153). 20372153
PubMed Id Reference Title Details
(20372153) Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. Full reference...